FBXW2 Rabbit Polyclonal Antibody from Bioassay Technology Laboratory

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif: the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact: F-box proteins are one of the four subunits of ubiquitin protein ligases: called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats: leucine-rich repeats: or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats